Performance & longevity

Creatine, urolithin A, amino acids, electrolytes and other targeted supplements, held to the research on each ingredient.

How we rank performance & longevity

  • Ingredients 25%
  • Independent testing 30%
  • Evidence 25%
  • Trust 10%
  • Value 10%
Why, and what each one means

We rank supplements on what is in them, whether someone the maker does not pay has tested them, how strong the human research is at the label dose, the maker's record and price per day. Plain creatine monohydrate scores highest: its research is deep and shows it is safe for healthy adults (ISSN position stand (opens in a new tab), our guide). Amino acid mixes rest on low-certainty trials (PubMed (opens in a new tab)), urolithin A on a few small ones (PubMed (opens in a new tab)). A paid seal alone earns a middle score.

Ingredients 25%
Highest for one or a few ingredients, all named, with nothing artificial and no fragrance (named essential oils are fine). Each unnecessary additive, unnamed flavor, sweetener or preservative costs points.
Independent testing 30%
Highest when someone the maker does not pay (a consumer group, journalist, university or regulator) has tested it for the contaminants that matter here and published clean results. A certification the maker pays for, or the maker’s own lab reports, count for less, and claims with nothing published count for little.
Evidence 25%
How strong the human research is for this ingredient at this dose: many trials score high, a few small or maker-funded ones score low.
Trust 10%
Highest when the maker names everything, answers questions, and has no recalls, warning letters, Prop 65 notices or lawsuits over safety or labeling. Points come off for unresolved problems and for paid promoters it does not disclose.
Value 10%
Price per day’s dose against the others here that pass.

Each product scores every one from 1 to 5, and its rating is the weighted average. We list only products rated 3 or above that break none of our rules.

  • Proprietary blends, “clinically dosed” claims that name no study, and “utilization” or absorption percentages with no published method.
  • Gummies and chews with no third-party test. They are hard to dose accurately.
  • Anti-aging, “cellular renewal” or hangover-cure claims without a placebo-controlled trial in people at the label dose.

Know one that fits? Suggest a product

Weekly research digest

New topics and updated research, once a week when there's something new. How it works